Primary Sclerosing Cholangitis: Therapeutic Options and Surveillance Management
نویسندگان
چکیده
منابع مشابه
Primary Sclerosing Cholangitis: Therapeutic Options and Surveillance Management
Primary sclerosing cholangitis is a chronic immune-mediated liver disease. Though rare, it poses several clinical concerns for the managing physician. There are currently limited therapeutic options in the management of the condition and weak evidence base behind them. Endoscopic intervention is limited to those patients with obstructing stricture-related disease, and even liver transplantation...
متن کاملNew Therapeutic Strategies for Primary Sclerosing Cholangitis.
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease, which in the majority of patients progresses to liver transplantation or death. To date, no medical treatment has been proven to be of benefit, although ursodeoxycholic acid is widely used. The etiopathogenesis of PSC is unclear, although it is associated with inflammatory bowel disease. Various hypotheses have been su...
متن کاملPrimary sclerosing cholangitis: diagnostic and management challenges
Primary sclerosing cholangitis (PSC) is a chronic immune-mediated disease affecting intra- and extrahepatic bile ducts, primarily the large biliary ducts. Clinical manifestations are broad, and the spectrum encompasses asymptomatic cholestasis, icteric cholangitis with pruritis, cirrhosis, and cholangiocarcinoma. Though rare, PSC has a propensity to affect young to middle-aged males and is stro...
متن کاملPrimary sclerosing cholangitis: etiopathogenesis and clinical management.
Primary sclerosing cholangitis (PSC) is a chronic inflammatory liver disease characterized by the destruction of medium to large-sized bile ducts and intense, concentric fibrosis. Complications from PSC include bacterial cholangitis, cirrhosis, and cholangiocarcinoma and a therapy that might alter the natural history of the disease remains lacking. Our understanding of the pathogenesis of PSC a...
متن کاملCurrent management of primary biliary cirrhosis and primary sclerosing cholangitis.
Primary biliary cirrhosis (PBC) is a chronic, cholestatic autoimmune liver disease characterized by inflammation and progressive destruction of interlobular bile ducts, ultimately leading to biliary cirrhosis. Population based studies have estimated the incidence of PBC as 19.1–251/ 1 000 000 in the general population [1,2]. The etiology of PBC is attributed to autoimmunity mainly due to the as...
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ژورنال
عنوان ژورنال: Clinical Medicine Insights: Gastroenterology
سال: 2016
ISSN: 1179-5522,1179-5522
DOI: 10.4137/cgast.s38451